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In 3 separate controlled, parallel group clinical pharmacology studies, clarinex-d at the clinical dose of 5 mg has been co-administered with azithromycin 500 mg followed by 250 mg once daily for 4 days n 18 or with fluoxetine 20 mg once daily for 7 days after a 23-day pretreatment period with fluoxetine n 18 or with cimetidine 600 mg every 12 hours for 14 days n 18 under steady state conditions to healthy male and female subjects.

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5 mg, and 50 mg , paroxetine c max and auc 0-inf increased disproportionately with dose as seen also with immediate-release formulations .

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