In 3 separate controlled, parallel group clinical pharmacology studies, clarinex-d at the clinical dose of 5 mg has been co-administered with azithromycin 500 mg followed by 250 mg once daily for 4 days n 18 or with fluoxetine 20 mg once daily for 7 days after a 23-day pretreatment period with fluoxetine n 18 or with cimetidine 600 mg every 12 hours for 14 days n 18 under steady state conditions to healthy male and female subjects.
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CommentsThe full effect may be delayed until after at least 4 weeks of treatmentThe potential risks versus clinical need should be assessed prior to using this drug in children and adolescents.
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plasma exposures auc to fluoxetine in juvenile rats receiving 3, 10, or 30 mg kg day doses in this study are approximately 0.